Opportunity Information: Apply for W81XWH 18 TSCRP IDA

The DoD Tuberous Sclerosis Complex (TSC) Idea Development Award (Funding Opportunity Number: W81XWH 18 TSCRP IDA) is a discretionary research funding opportunity administered by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It falls under the Science and Technology and other Research and Development category (CFDA 12.420) and is offered through either a grant or a cooperative agreement, depending on the structure and oversight needs of the proposed work. The program is designed to push the field forward by backing research concepts that are genuinely innovative and positioned to open up new directions in TSC science and, ultimately, improve patient care.

At its core, this award emphasizes idea-driven, high-impact research rather than incremental extensions of existing work. The intent is to support projects that can produce meaningful findings and create fresh avenues for investigation in tuberous sclerosis complex, whether those advances relate to disease biology, diagnostics, therapeutic strategies, or clinical management. While the mechanism is framed around innovation, it is not intended for purely speculative concepts; proposals are expected to be grounded in a clear scientific rationale and supported by strong preliminary data that makes the central idea credible and testable.

A key requirement is that the proposed research includes a well-formulated, testable hypothesis. In practical terms, the opportunity is looking for applications that present a coherent story: a defined gap or problem in TSC research or care, a novel concept to address that problem, evidence suggesting the concept is plausible, and a study design that can rigorously test the hypothesis. This structure reflects the program's focus on funding research that is both creative and realistically capable of producing interpretable results that could lead to critical discoveries or tangible clinical improvements.

Eligibility is described as unrestricted, meaning it is broadly open to any type of applicant organization or entity, with the caveat that applicants should review any additional eligibility clarifications that may be provided in the full announcement text. The opportunity was originally posted on May 14, 2018, with an original closing date of August 2, 2018. The announcement indicated an expectation of approximately four awards. The listed award ceiling is shown as 0, which typically signals that a specific maximum dollar amount was not provided in the summary field and would need to be confirmed in the full solicitation details or related program guidance.

Overall, this funding opportunity is best understood as a targeted investment in bold but well-supported TSC research ideas, with an explicit preference for proposals that combine conceptual innovation with a strong evidence base and a clear path to generating high-impact results for the TSC research community and for patients.

  • The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tuberous Sclerosis Complex Idea Development Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on May 14, 2018.
  • Applicants must submit their applications by Aug 02, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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