Opportunity Information: Apply for PA 20 265
The PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer (STTR) Grant Applications, listed as PA 20-265, is a National Institutes of Health (NIH) funding opportunity designed to support U.S. small businesses that want to pursue early-stage research and development in partnership with a research institution. It sits under the broader NIH STTR program structure and uses the standard STTR mechanisms R41 (Phase I) and R42 (Phase II). The core purpose is to help small business concerns (SBCs) translate innovative scientific ideas into technologies, products, and services that align with the research and development missions of NIH awarding components, while also leveraging the expertise and resources of a collaborating nonprofit research institution.
A key feature of this announcement is that it is a "Parent" STTR solicitation, meaning it is not limited to one narrow disease area or one specialized initiative. Instead, it provides an umbrella pathway for applicants to submit proposals across a wide range of NIH-relevant topics, as long as the work fits within the scope of the participating NIH Institutes and Centers. Applicants are expected to align their proposals with the specific research topic areas referenced through the NIH, CDC, and FDA SBIR/STTR program descriptions and topic listings (noted in the opportunity text as PHS 2019-2 SBIR/STTR Program Descriptions and Research Topics). In practice, this means the solicitation is broad, but not unfocused: the proposed project still needs to map clearly onto an identified topic area and the mission priorities of the relevant NIH component.
This particular Parent FOA explicitly does not allow clinical trials. That restriction is important because it shapes what kinds of human-focused research can be proposed. Projects may still be clinical in orientation in the general sense (for example, developing diagnostics, devices, therapeutics, software, or platforms meant for healthcare settings), but the application cannot include a clinical trial as defined by NIH policy. Applicants who need to run a clinical trial must look for a different FOA that allows clinical trials, because submitting a clinical trial under this one would make the application noncompliant.
Eligibility is centered on U.S. small businesses. The eligible applicant type is small businesses, specifically United States small business concerns that meet STTR program requirements. Foreign institutions are not eligible to apply as the primary applicant, and non-U.S. components of U.S. organizations are also not eligible to apply as applicant organizations under this FOA. However, the announcement notes that foreign components, as defined in the NIH Grants Policy Statement, may be allowed in some circumstances. In plain terms, the awardee must be a qualifying U.S. small business, but certain parts of the work might be performed with foreign involvement if NIH rules permit and if it is well-justified, though the solicitation makes clear that non-domestic entities cannot be the applicant.
From an administrative and classification standpoint, this is a discretionary grant program (not a contract), offered by NIH. The activity categories tied to this opportunity are broad and span areas such as health, education, environment, food and nutrition, and income security/social services, reflecting how NIH-supported innovations can intersect with multiple public-impact domains. The solicitation is associated with many CFDA (Catalog of Federal Domestic Assistance) numbers (now commonly referenced under Assistance Listings), indicating participation across multiple NIH programs and Institutes and Centers. The opportunity was created on July 14, 2020, and the original closing date listed is April 5, 2021. The funding notice does not provide an award ceiling or an expected number of awards in the excerpt provided, which usually means applicants must rely on NIH STTR budget guidance and any Institute- or topic-specific limitations referenced in the full FOA and related policy documents.
Overall, this opportunity is best understood as a major entry point for U.S. small businesses that want to develop NIH-relevant innovations through the STTR model, where collaboration with a research institution is a defining element, and where the supported R and D must stop short of conducting a clinical trial under this specific announcement. The strongest applications are typically those that clearly define the technical innovation, justify the public health or biomedical relevance to NIH priorities, demonstrate a credible path from feasibility (Phase I) to further development (Phase II), and show that the small business and its partnering research institution have the combined expertise, resources, and execution plan to move the technology toward real-world impact without proposing a disallowed clinical trial component.Apply for PA 20 265
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.307, 93.350, 93.351, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.837, 93.838, 93.846, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866, 93.867, 93.879.
- This funding opportunity was created on 2020-07-14.
- Applicants must submit their applications by 2021-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 20 265) also looked into and applied for these:
| Funding Opportunity |
|---|
| Successor-in-Interest (Type 6 Parent Clinical Trial Optional) Apply for PA 20 275 Funding Number: PA 20 275 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 21 051 Funding Number: PA 21 051 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 21 050 Funding Number: PA 21 050 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity) Apply for PA 21 052 Funding Number: PA 21 052 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 21 049 Funding Number: PA 21 049 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 21 048 Funding Number: PA 21 048 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) Apply for PAR 21 038 Funding Number: PAR 21 038 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed) Apply for PA 21 071 Funding Number: PA 21 071 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 - Independent Clinical Trial Not Allowed) Apply for RFA OD 21 005 Funding Number: RFA OD 21 005 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed) Apply for PAR 21 169 Funding Number: PAR 21 169 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $100,000 |
| Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed) Apply for PAR 21 173 Funding Number: PAR 21 173 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $125,000 |
| Understanding and Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 Clinical Trial Optional) Apply for RFA MD 21 004 Funding Number: RFA MD 21 004 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $500,000 |
| Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) Apply for PAR 21 155 Funding Number: PAR 21 155 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $300,000 |
| Change of Recipient Organization (Type 7 Parent Clinical Trial Optional) Apply for PA 21 268 Funding Number: PA 21 268 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 21 262 Funding Number: PA 21 262 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 21 259 Funding Number: PA 21 259 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 21 260 Funding Number: PA 21 260 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Phenotyping Project Data Coordination Center and Database (UM1 Clinical Trial Not Allowed) Apply for RFA HG 21 037 Funding Number: RFA HG 21 037 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) Clinical Trial Not Allowed Apply for RFA HG 21 036 Funding Number: RFA HG 21 036 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed) Apply for PA 21 345 Funding Number: PA 21 345 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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