Opportunity Information: Apply for PA 19 086
The Mentored Clinical Scientist Research Career Development Award (K08) under PA-19-086 is an NIH career development grant meant to help clinically trained researchers become independent investigators whose work addresses important U.S. health research needs. The core idea is to give early-career professionals with a clinical doctoral degree sustained, protected time to build deep research expertise under the guidance of experienced mentors. It supports an intensive, supervised career development period in biomedical and behavioral research, including translational research, with the expectation that recipients will come out of the award positioned to compete successfully for independent research funding and to lead impactful research programs.
What makes this specific K08 announcement distinct is that it is tailored to applicants who will lead independent basic experimental studies involving humans. NIH treats these projects as clinical trials because they prospectively involve human participants and assign them to conditions, but they are also considered basic research because the intent is to understand fundamental mechanisms or phenomena rather than to test a product or directly develop an applied intervention. In practical terms, the projects targeted here are ones where the investigator experimentally manipulates an independent variable in people and measures biomedical or behavioral outcomes to answer basic science questions, without a primary goal of creating or optimizing a process, treatment, device, or other product. If the proposed human study is experimental but is aimed at a specific practical application or product-focused development pathway, NIH indicates that it should be submitted to the companion opportunity (PA-18-372) rather than to this FOA.
The funding instrument is a grant, and the opportunity sits within broad public-purpose categories that include education, environment, health, and social services. It is administered by the National Institutes of Health and is associated with multiple CFDA numbers (93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.307, 93.853, 93.865, 93.866, 93.867), reflecting that different NIH institutes and centers participate and may support K08 awards aligned with their missions.
Eligibility is wide on the applicant organization side. Eligible applicants include many types of U.S. organizations and governmental entities, such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (other than small businesses), small businesses, and a variety of government bodies (state, county, city/township, special district governments, independent school districts, and certain housing authorities). Tribal entities are included as well, both federally recognized Native American tribal governments and tribal organizations that are not federally recognized. The announcement also highlights additional eligible applicant categories often emphasized for NIH participation, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
At the same time, NIH draws clear lines around foreign involvement at the applicant level. Non-domestic (non-U.S.) entities and non-U.S. institutions are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, meaning the research program may include certain foreign collaborations or elements when justified and compliant with NIH policy, even though the primary applicant organization must be domestic.
Key administrative details in the source information include the funding opportunity title and number (Mentored Clinical Scientist Research Career Development Award (Parent K08 - Independent Basic Experimental Studies with Humans Required), PA-19-086), the original closing date listed as 2020-05-12, and the creation date of 2018-11-28. The award ceiling and expected number of awards are not specified in the provided data, which is common in NIH FOAs where budgets and award counts can vary by institute, fiscal year, and program priorities.Apply for PA 19 086
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Mentored Clinical Scientist Research Career Development Award (Parent K08 - Independent Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.307, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2018-11-28.
- Applicants must submit their applications by 2020-05-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Mentored Clinical Scientist Research Career Development Award (K08) under PA-19-086?
PA-19-086 is an NIH career development grant (K08) designed to help clinically trained researchers transition into independent investigators. It provides sustained, protected time for early-career professionals with a clinical doctoral degree to build strong research expertise through an intensive, supervised career development period.
What is the main goal of this K08 opportunity?
The main goal is to support a structured, mentored career development experience that positions award recipients to compete successfully for independent research funding and to lead impactful biomedical or behavioral research programs that address important U.S. health research needs.
What type of research does this announcement emphasize?
This K08 emphasizes biomedical and behavioral research, including translational research, conducted as part of a mentored and supervised career development plan.
What makes PA-19-086 distinct from other K08 announcements?
This specific K08 announcement is tailored to applicants who will lead independent basic experimental studies involving humans. NIH treats these projects as clinical trials because they prospectively involve human participants and assign them to conditions, while still being considered basic research because the intent is to understand fundamental mechanisms or phenomena rather than to test a product or develop an applied intervention.
Does this FOA require studies involving humans?
Yes. The focus is on independent basic experimental studies involving humans, where participants are prospectively assigned to conditions as part of the experimental design.
Why does NIH consider these projects "clinical trials" if they are basic research?
NIH considers them clinical trials because they prospectively involve human participants and assign them to conditions. They are considered basic research when the intent is to understand fundamental mechanisms or phenomena rather than to test a product or pursue a direct applied development pathway.
What is meant by "independent basic experimental studies with humans" in practical terms?
In practical terms, the projects targeted are ones where the investigator experimentally manipulates an independent variable in people and measures biomedical or behavioral outcomes to answer basic science questions. The primary goal is not to create, optimize, or test a product, treatment, device, or other applied intervention.
If my human study is experimental but aimed at a practical application (like a product or intervention), should I apply to PA-19-086?
No. NIH indicates that if the proposed human study is experimental but aimed at a specific practical application or a product-focused development pathway, it should be submitted to the companion opportunity PA-18-372 rather than PA-19-086.
What is the funding instrument for PA-19-086?
The funding instrument is a grant.
Which federal agency administers this opportunity?
This opportunity is administered by the National Institutes of Health (NIH).
What broad public-purpose categories does this opportunity fall under?
The opportunity sits within broad public-purpose categories that include education, environment, health, and social services.
Which CFDA numbers are associated with this K08 opportunity?
The opportunity is associated with multiple CFDA numbers: 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.307, 93.853, 93.865, 93.866, and 93.867. This reflects participation by multiple NIH institutes and centers that may support K08 awards aligned with their missions.
What types of U.S. organizations are eligible to apply?
Eligible applicant organizations include a wide range of U.S. entities, such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (other than small businesses), small businesses, and multiple levels and types of government bodies (state, county, city/township, special district governments, independent school districts, and certain housing authorities).
Are tribal entities eligible to apply?
Yes. Eligibility includes federally recognized Native American tribal governments and tribal organizations that are not federally recognized.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are listed among eligible applicant categories.
Does NIH highlight any specific institution types as eligible applicants?
Yes. The announcement highlights categories often emphasized for NIH participation, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs). It also notes faith-based or community-based organizations, eligible federal agencies, and regional organizations.
Can a non-U.S. (foreign) organization apply as the applicant organization?
No. Non-domestic (non-U.S.) entities and non-U.S. institutions are not eligible to apply as the applicant organization.
Are non-domestic components of U.S. organizations eligible?
No. Non-domestic components of U.S. organizations are not eligible.
Are foreign collaborations allowed at all under this FOA?
Yes. While the primary applicant organization must be domestic, foreign components (as defined in the NIH Grants Policy Statement) are allowed. This means the research program may include certain foreign collaborations or elements when justified and compliant with NIH policy.
What is the funding opportunity title and number?
The title and number are: Mentored Clinical Scientist Research Career Development Award (Parent K08 - Independent Basic Experimental Studies with Humans Required), PA-19-086.
What are the key dates provided for this opportunity?
The creation date listed is 2018-11-28, and the original closing date listed is 2020-05-12.
Is there an award ceiling listed for this opportunity?
No. The award ceiling is not specified in the provided information.
Is the expected number of awards listed?
No. The expected number of awards is not specified in the provided information. This can be common in NIH funding opportunity announcements where budgets and award counts vary by institute, fiscal year, and program priorities.
Why might budget limits or award counts be missing from the provided details?
The provided information notes that this is common in NIH FOAs because budgets and the number of awards can vary depending on the participating institute or center, the fiscal year, and program priorities.
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