Opportunity Information: Apply for RFA HL 22 010
The Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01 Independent Clinical Trial Required), RFA-HL-22-010, is a National Institutes of Health (NIH) funding opportunity from the National Heart, Lung, and Blood Institute (NHLBI) focused on strengthening the pipeline of independent biomedical researchers from diverse backgrounds, including investigators from groups that are underrepresented in NHLBI-relevant research areas. The award is structured as a mentored career development grant, meaning the central goal is to provide protected time, training, and supervised research experiences that help an early-career faculty member build the skills, publication record, and scientific direction needed to transition to research independence.
Scientifically, the FOA is aimed at investigators working in biomedical, behavioral, or clinical research connected to NHLBI mission areas, specifically cardiovascular, pulmonary, and hematologic diseases as well as sleep disorders. It emphasizes research that uses advanced methods and experimental approaches, and it highlights relevance both to the general population and to health disparities populations. In practice, this means the program is looking for candidates whose research plans are not only important to these disease areas, but are also technically and conceptually strong enough to position the candidate as an emerging leader with a clear path toward future independent funding.
A defining feature of this particular K01 announcement is the clinical trial requirement. It is intended for candidates who will serve as the lead investigator of an independent clinical trial, an independent clinical trial feasibility study, or an ancillary study tied to an existing trial, as long as the candidate is leading that ancillary clinical trial as a separate, stand-alone effort. The FOA draws a clear line between leading an independent trial and simply participating in a trial run by someone else. If a candidate is not proposing an independent clinical trial (for example, if they plan to gain experience by working on a mentor-led trial without being the lead investigator), they are directed instead to the companion FOA, RFA-HL-22-011. This distinction matters because the training plan, oversight, and evaluation of readiness for independence are built around the candidate taking primary responsibility for the design and conduct of the clinical study.
Applications are submitted by institutions on behalf of eligible faculty candidates, with the expectation that the candidate will work closely with an accomplished mentor who has both deep expertise in the proposed research area and a demonstrated record of developing independent investigators. The mentored structure is central: the award supports a deliberate career development plan (skills, coursework or workshops where appropriate, structured mentoring, and research milestones) alongside a research project that produces meaningful outputs and advances the candidate toward an independent research trajectory.
The eligible applicant landscape is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other categories specified by NIH. The announcement also explicitly calls out additional eligible organizational types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. While foreign components may be allowed under NIH policy definitions, non-U.S. organizations and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible.
Administratively, this is a discretionary grant program in the health funding category, associated with CFDA numbers 93.233, 93.837, 93.838, 93.839, and 93.840. The sponsoring agency is NIH, and the FOA record lists an original closing date of 2024-05-07. The award ceiling and expected number of awards are not specified in the provided source information, so applicants typically need to consult the full FOA text and NIH budget and K-award policy guidance for allowable costs, effort expectations, and institute-specific budget parameters.
In short, this opportunity is designed for early-stage faculty who are ready to grow into independent NHLBI-relevant investigators and who can credibly lead an independent clinical trial (or feasibility/ancillary clinical trial) as the centerpiece of their mentored research and career development plan, supported by a strong mentoring team and an institution positioned to provide the environment and protected time needed to reach independence.Apply for RFA HL 22 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01 Independent Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
- This funding opportunity was created on 2021-05-25.
- Applicants must submit their applications by 2024-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01 Independent Clinical Trial Required)?
This opportunity (RFA-HL-22-010) is a mentored career development award from the National Institutes of Health (NIH), specifically the National Heart, Lung, and Blood Institute (NHLBI). It is designed to strengthen the pipeline of independent biomedical researchers from diverse backgrounds, including investigators from groups that are underrepresented in NHLBI-relevant research areas, by providing protected time, training, mentored research experiences, and a structured career development plan.
Which NIH Institute is sponsoring this funding opportunity?
The sponsoring agency is NIH, and the participating Institute described here is the National Heart, Lung, and Blood Institute (NHLBI).
What is the FOA number and title?
The FOA is RFA-HL-22-010, titled "Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01 Independent Clinical Trial Required)."
What is the main purpose of this K01 award?
The central goal is to support an early-career faculty member with protected time, training, and supervised research so they can build the skills, publication record, and scientific direction needed to transition to research independence in NHLBI mission areas.
Who is this award intended to support?
It is intended for early-career faculty candidates who are positioned to develop into independent investigators and who can credibly lead an independent clinical trial (or an independent feasibility/ancillary clinical trial) as part of their mentored research and career development plan.
What research areas are considered responsive to this FOA?
The FOA targets biomedical, behavioral, or clinical research connected to NHLBI mission areas, specifically cardiovascular, pulmonary, and hematologic diseases, as well as sleep disorders.
Does the FOA emphasize any particular approach or type of impact?
Yes. It emphasizes research that uses advanced methods and experimental approaches and highlights relevance both to the general population and to health disparities populations.
Is a clinical trial required under this specific K01 announcement?
Yes. A defining feature of RFA-HL-22-010 is that it is intended for candidates who will serve as the lead investigator of an independent clinical trial, an independent clinical trial feasibility study, or an ancillary study tied to an existing trial, provided the candidate is leading that ancillary clinical trial as a separate, stand-alone effort.
What does "Independent Clinical Trial Required" mean in practice?
It means the candidate must take primary responsibility as the lead investigator for the design and conduct of their proposed clinical study (independent trial, feasibility study, or stand-alone ancillary clinical trial). The FOA distinguishes this from simply participating in a clinical trial led by someone else.
What if a candidate plans to work on a mentor-led clinical trial rather than lead their own trial?
If the candidate is not proposing an independent clinical trial (for example, if they plan to gain experience by working on a mentor-led trial without being the lead investigator), they are directed to the companion FOA, RFA-HL-22-011.
What types of clinical trial activities are explicitly allowed for the candidate to lead?
The FOA states the candidate may lead (1) an independent clinical trial, (2) an independent clinical trial feasibility study, or (3) an ancillary study linked to an existing trial, as long as the candidate leads that ancillary clinical trial as a separate, stand-alone effort.
How is this award structured (mentored vs. independent)?
This is a mentored career development award. The structure is built around a deliberate career development plan (such as skill-building, coursework or workshops when appropriate, structured mentoring, and defined milestones) alongside a research project that produces meaningful outputs and supports progression toward independent funding.
Who submits the application: the candidate or the institution?
Applications are submitted by eligible institutions on behalf of eligible faculty candidates.
What is expected of the mentor?
The candidate is expected to work closely with an accomplished mentor who has deep expertise in the proposed research area and a demonstrated record of developing independent investigators.
Why is the mentored structure emphasized in this FOA?
The mentored structure is central because the award is meant to provide a supervised and structured path to independence, combining training and mentoring with a focused research project and measurable career development milestones.
What kinds of organizations are eligible to apply?
The eligible applicant landscape is broad and includes many U.S.-based organizations and governmental entities. Examples listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other categories specified by NIH.
Are minority-serving institutions and community-based organizations eligible?
Yes. The announcement explicitly calls out eligible organizational types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs). It also notes faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Are non-U.S. organizations or foreign institutions eligible to apply?
No. Non-U.S. organizations and foreign institutions are not eligible to apply.
Are non-domestic components of U.S. organizations eligible?
No. Non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed at all?
The information provided indicates that foreign components may be allowed under NIH policy definitions, but non-U.S. organizations and foreign institutions cannot apply, and non-domestic components of U.S. organizations are not eligible.
What is the funding category and program type?
This is a discretionary grant program in the health funding category.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.233, 93.837, 93.838, 93.839, and 93.840.
What is the closing date listed for this FOA record?
The FOA record lists an original closing date of 2024-05-07.
How many awards will be made, and what is the funding ceiling?
The award ceiling and the expected number of awards are not specified in the information provided. Applicants are typically expected to consult the full FOA text and NIH budget and K-award policy guidance for allowable costs, effort expectations, and institute-specific budget parameters.
What makes a candidate a strong fit based on the description provided?
Based on the provided description, a strong fit is an early-stage faculty candidate whose research aligns with NHLBI mission areas, is technically and conceptually strong, demonstrates relevance to the general population and/or health disparities populations, and includes a credible plan for the candidate to lead an independent clinical trial (or feasibility/stand-alone ancillary clinical trial) supported by a strong mentoring team and an institution able to provide an appropriate environment and protected time.
What is the role of the institution in this award?
The institution applies on behalf of the candidate and is expected to be positioned to provide the environment and protected time needed for the candidate to complete the career development plan and progress toward research independence.
How does this FOA describe the path to independence?
The FOA frames the path to independence as a combination of protected time, targeted training, structured mentoring, and a supervised research experience that yields meaningful outputs (such as publications and clear scientific direction) and positions the candidate for future independent funding.
What is the key distinction between RFA-HL-22-010 and its companion FOA?
The key distinction described is whether the candidate will lead an independent clinical trial. RFA-HL-22-010 is for candidates who will be the lead investigator of an independent clinical trial (or feasibility/stand-alone ancillary clinical trial). Candidates who are not proposing to lead an independent clinical trial and instead will gain experience via a mentor-led trial are directed to RFA-HL-22-011.
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| NIA Advanced Postdoctoral Career Transition Awards to Promote Diversity in Translational Research for AD/ADRD (K99/R00 Clinical Trial Not Allowed) Apply for PAR 21 220 Funding Number: PAR 21 220 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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