Opportunity Information: Apply for RFA DA 25 070
The National Institutes of Health (NIH) is offering a discretionary grant opportunity titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional)" under funding opportunity number RFA-DA-25-070 (CFDA 93.279). The core aim is to fund projects that test enhanced, real-world models of care that more effectively bring together HIV services, addiction-related services, and routine primary care in a coordinated way. The emphasis is on integration that is practical and optimized for patients who often have overlapping needs, with the larger public health goal of reducing HIV transmission and improving outcomes for people living with or at risk for HIV who also experience substance use disorders and other health conditions typically addressed in primary care.
This opportunity uses the NIH R34 mechanism, which is commonly used to support the early-stage development, refinement, and preliminary testing of interventions or service delivery models before a larger, definitive study. The "Clinical Trial Optional" designation means applicants may propose a study that meets NIH's definition of a clinical trial, but they are not required to do so; applicants can also propose other rigorous testing and evaluation approaches appropriate for service integration research. In practical terms, the NOFO is looking for applicants to move beyond describing an integrated care concept and instead actually test an enhanced model, generating evidence about feasibility, acceptability, implementation, and early signals of impact in settings where HIV, addiction, and primary care intersect.
A wide range of applicants are eligible, reflecting NIH's intent to support work across different health systems and community contexts. Eligible entities include state, county, city or township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; and federally recognized Native American tribal governments, as well as Native American tribal organizations other than federally recognized tribal governments. The NOFO is also open to public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (excluding institutions of higher education when applicable), for-profit organizations other than small businesses, and small businesses. In addition, NIH explicitly highlights other eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISI); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; and even non-U.S. entities (foreign organizations), which signals an openness to a broad set of partnerships and implementation environments.
Key administrative details include an original application due date of March 19, 2025, and an award ceiling of $450,000. The opportunity was created on October 15, 2024, and is categorized under education and health within NIH's discretionary grant programs. While the notice does not list the expected number of awards in the provided excerpt, the ceiling clarifies the maximum budget level NIH anticipates per award under this call, and applicants should plan a project scope that fits within that limit while still producing a meaningful test of an integrated service model.
Overall, this NOFO is geared toward organizations that can realistically implement and evaluate improved, coordinated care approaches that link HIV prevention and treatment with addiction services and primary care. Competitive proposals will generally be those that can show a strong understanding of the target population and care gaps, build credible integration strategies across clinical and community systems, and use solid evaluation methods to demonstrate whether the enhanced model works in practice and can be sustained or scaled.Apply for RFA DA 25 070
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2024-10-15.
- Applicants must submit their applications by 2025-03-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $450,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional)."
What is the funding opportunity number and CFDA listing?
The funding opportunity number is RFA-DA-25-070, and the CFDA listing provided is 93.279.
What is the main goal of this grant?
The main goal is to fund projects that test enhanced, real-world models of care that more effectively integrate HIV services, addiction-related services, and routine primary care in a coordinated way, with an emphasis on practical integration optimized for patients with overlapping needs.
What public health outcomes is this opportunity trying to support?
The opportunity is oriented toward reducing HIV transmission and improving outcomes for people living with or at risk for HIV who also experience substance use disorders and other health conditions typically addressed in primary care.
What does "integrated HIV/AIDS, addiction, and primary care services" mean in this NOFO?
In this NOFO, integration refers to coordinated care approaches that bring together HIV prevention and treatment services, addiction-related services, and routine primary care in ways that work in real-world settings where these needs often intersect.
What grant mechanism is being used?
This opportunity uses the NIH R34 mechanism, which is commonly intended for early-stage development, refinement, and preliminary testing of interventions or service delivery models before a larger, definitive study.
What does R34 support in practical terms for this announcement?
R34 support here is aimed at moving beyond describing an integrated care concept and instead testing an enhanced model to generate evidence about feasibility, acceptability, implementation, and early signals of impact.
What does "Clinical Trial Optional" mean?
"Clinical Trial Optional" means an applicant may propose a study that meets NIH's definition of a clinical trial, but it is not required. Applicants may also propose other rigorous testing and evaluation approaches suitable for service integration research.
Is a clinical trial required to apply?
No. A clinical trial may be proposed, but it is not required under the "Clinical Trial Optional" designation.
What types of projects are most aligned with what NIH is asking for?
Projects that actually test an enhanced integrated service model in real-world settings, using solid evaluation methods and producing evidence on feasibility, acceptability, implementation, and early signals of impact, are most aligned with this announcement.
Does NIH want conceptual models, or tested models?
The emphasis is on testing an enhanced model, not only describing an integrated care concept.
What kinds of settings does this opportunity focus on?
The opportunity emphasizes settings where HIV services, addiction-related services, and primary care intersect, including clinical and community systems that can realistically implement and evaluate coordinated care approaches.
Who is eligible to apply?
A wide range of applicants are eligible, including various government entities, higher education institutions, nonprofits, for-profits (other than small businesses), and small businesses, as well as several explicitly highlighted organization types and even non-U.S. entities.
Are state, county, city, or township governments eligible?
Yes. State, county, city, or township governments are listed as eligible applicants.
Are special district governments eligible?
Yes. Special district governments are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are listed as eligible applicants.
Are public housing authorities or Indian housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are federally recognized Native American tribal governments eligible?
Yes. Federally recognized Native American tribal governments are listed as eligible applicants.
Are Native American tribal organizations that are not federally recognized eligible?
Yes. Native American tribal organizations (other than federally recognized tribal governments) are included as eligible.
Are public or state-controlled institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education are listed as eligible applicants.
Are private institutions of higher education eligible?
Yes. Private institutions of higher education are listed as eligible applicants.
Are nonprofits eligible?
Yes. Nonprofits with or without 501(c)(3) status are eligible (excluding institutions of higher education when applicable, as stated in the provided information).
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also separately listed as eligible.
Are small businesses eligible?
Yes. Small businesses are listed as eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly highlighted as eligible applicant types.
Are Historically Black Colleges and Universities (HBCUs) eligible?
Yes. HBCUs are explicitly highlighted as eligible applicant types.
Are Hispanic-serving Institutions eligible?
Yes. Hispanic-serving Institutions are explicitly highlighted as eligible applicant types.
Are Tribally Controlled Colleges and Universities (TCCUs) eligible?
Yes. TCCUs are explicitly highlighted as eligible applicant types.
Are Alaska Native and Native Hawaiian Serving Institutions eligible?
Yes. Alaska Native and Native Hawaiian Serving Institutions are explicitly highlighted as eligible applicant types.
Are AANAPISI institutions eligible?
Yes. Asian American Native American Pacific Islander Serving Institutions (AANAPISI) are explicitly highlighted as eligible applicant types.
Are eligible federal agencies able to apply?
Yes. Eligible federal agencies are explicitly highlighted as eligible applicant types.
Are regional organizations eligible?
Yes. Regional organizations are explicitly highlighted as eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly highlighted as eligible applicant types.
Can non-U.S. (foreign) organizations apply?
Yes. Non-U.S. entities (foreign organizations) are explicitly noted as eligible, indicating openness to a broad set of implementation environments and partnerships.
What is the application due date?
The original application due date provided is March 19, 2025.
When was this funding opportunity created?
The opportunity was created on October 15, 2024.
What is the maximum award amount (award ceiling)?
The award ceiling listed is $450,000.
How should applicants think about project scope given the award ceiling?
Applicants should plan a project scope that fits within the $450,000 ceiling while still producing a meaningful test of an integrated service model and generating evidence on feasibility, acceptability, implementation, and early signals of impact.
Does the provided information state how many awards NIH expects to make?
No. The excerpt provided does not list the expected number of awards.
How is this opportunity categorized?
It is categorized under education and health within NIH's discretionary grant programs, based on the information provided.
What kinds of evaluation outcomes are emphasized?
The announcement emphasizes generating evidence about feasibility, acceptability, implementation, and early signals of impact for the enhanced integrated model of care.
What factors are described as characteristic of competitive proposals?
Competitive proposals are described as those that show a strong understanding of the target population and care gaps, build credible integration strategies across clinical and community systems, and use solid evaluation methods to demonstrate whether the enhanced model works in practice and can be sustained or scaled.
What populations are specifically highlighted as a focus?
The focus includes people living with or at risk for HIV who also experience substance use disorders and other health conditions typically addressed in primary care.
Does the NOFO prioritize sustainability or scalability?
The information provided indicates that strong proposals will generally aim to demonstrate whether the enhanced model can be sustained or scaled, in addition to whether it works in practice.
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| Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial required) Apply for RFA DA 25 072 Funding Number: RFA DA 25 072 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed) Apply for PAR 25 074 Funding Number: PAR 25 074 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required) Apply for PAR 26 001 Funding Number: PAR 26 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Co-infection and Cancer (R01 Clinical Trial Not Allowed) Apply for PAR 25 082 Funding Number: PAR 25 082 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Small Grants Program for Cancer Research (NCI Omnibus) (R03 Clinical Trial Optional) Apply for PAR 25 078 Funding Number: PAR 25 078 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed) Apply for PAR 25 130 Funding Number: PAR 25 130 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Targeting Inflammasomes in HIV and Substance Use (R21 Clinical Trial Not Allowed) Apply for RFA DA 25 068 Funding Number: RFA DA 25 068 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed) Apply for PAR 25 131 Funding Number: PAR 25 131 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Targeting Inflammasomes in HIV and Substance Use (R01 Clinical Trial Not Allowed) Apply for RFA DA 25 069 Funding Number: RFA DA 25 069 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed) Apply for PAR 24 268 Funding Number: PAR 24 268 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Mechanistic links between diet, lipid metabolism, and tumor growth and progression (UH2 Clinical Trial Not Allowed) Apply for PAR 25 118 Funding Number: PAR 25 118 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) Apply for PAR 25 211 Funding Number: PAR 25 211 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) Apply for PAR 25 210 Funding Number: PAR 25 210 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanistic links between diet, lipid metabolism, and tumor growth and progression (U01 Clinical Trial Not Allowed) Apply for PAR 25 119 Funding Number: PAR 25 119 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional) Apply for PAR 25 139 Funding Number: PAR 25 139 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Addressing Challenges in Detecting New Drugs: Instrumentation for Alternative Analytical Methods (R43/R44 - Clinical Trials Optional) Apply for RFA DA 26 018 Funding Number: RFA DA 26 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Addressing Challenges in Detecting New Drugs: Instrumentation for Alternative Analytical Methods (R41/R42 - Clinical Trials Optional) Apply for RFA DA 26 019 Funding Number: RFA DA 26 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Cancer Prevention and Control Clinical Trials Planning Grant Program (R34 Clinical Trials Optional) Apply for PAR 25 104 Funding Number: PAR 25 104 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Cancer Prevention and Control Clinical Trials Planning Grant Program (U34 Clinical Trials Optional) Apply for PAR 25 103 Funding Number: PAR 25 103 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Engaging Loved ones in Recovery Processes to Enhance Recovery Capital and Outcomes (R61/R33 Clinical Trial Optional) Apply for RFA DA 26 024 Funding Number: RFA DA 26 024 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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